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Limited gut cell repertoire for multiple hormones

Nature Cell Biology volume 20, pages 865–867 (2018)Cite this article

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Enteroendocrine (EE) cells secrete diverse peptide hormones, regulating food intake, digestion and metabolism. A study now challenges the traditional view that each hormone is the dominant product of a distinct EE cell type, showing that in response to local cues the same cell produces different hormones in different tissue compartments.

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Fig. 1: Models for hormonal specificity of gut EE cells.

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Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA

    Ramesh A. Shivdasani

  2. Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Ramesh A. Shivdasani

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  1. Ramesh A. Shivdasani
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Correspondence to Ramesh A. Shivdasani.

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Shivdasani, R.A. Limited gut cell repertoire for multiple hormones. Nat Cell Biol 20, 865–867 (2018). https://doi.org/10.1038/s41556-018-0153-9

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