Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.
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Hosios, A.M., Manning, B.D. Lysosomal catch-and-release controls mTORC1. Nat Cell Biol 20, 996–997 (2018). https://doi.org/10.1038/s41556-018-0188-y
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DOI: https://doi.org/10.1038/s41556-018-0188-y