Intra-tumour heterogeneity manifests both at the level of mutational burden, and at a functional level within genetically homogenous populations. A new modelling approach suggests stemness within colorectal tumours is defined by microenvironmental cues secreted from cancer-associated fibroblasts rather than cell-intrinsic properties.
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Flanagan, D. J. and Hodder, M. C. contributed equally.
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Flanagan, D.J., Hodder, M.C. & Sansom, O.J. Microenvironmental cues in cancer stemness. Nat Cell Biol 20, 1102–1104 (2018). https://doi.org/10.1038/s41556-018-0210-4
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DOI: https://doi.org/10.1038/s41556-018-0210-4
