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CLN8 safeguards lysosome biogenesis

Nature Cell Biology volume 20, pages 1333–1335 (2018)Cite this article

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Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.

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Fig. 1: CLN8 is an ER-export receptor for many soluble lysosomal proteins.

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  1. Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge School of Clinical Medicine, Cambridge, UK

    J. Paul Luzio

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  1. J. Paul Luzio
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Correspondence to J. Paul Luzio.

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Luzio, J.P. CLN8 safeguards lysosome biogenesis. Nat Cell Biol 20, 1333–1335 (2018). https://doi.org/10.1038/s41556-018-0240-y

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