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Targeting BAF-perturbed cancers

Nature Cell Biology volume 20, pages 1332–1333 (2018)Cite this article

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BAF is a heterogenous chromatin-remodelling complex, frequently mutated in cancer. A study now defines genome-wide localization patterns of three complexes, cBAF, PBAF and previously unknown ncBAF, and reveals the ncBAF complex as a specific vulnerability in synovial sarcoma and malignant rhabdoid tumours.

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Fig. 1: ncBAF is a vulnerability in SMARCB1 mutated cancers.

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Authors and Affiliations

  1. Stowers Institute for Medical Research, Kansas City, MO, USA

    Divya Reddy & Jerry L. Workman

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  1. Divya Reddy
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  2. Jerry L. Workman
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Correspondence to Jerry L. Workman.

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The authors declare no competing interests.

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Reddy, D., Workman, J.L. Targeting BAF-perturbed cancers. Nat Cell Biol 20, 1332–1333 (2018). https://doi.org/10.1038/s41556-018-0246-5

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