Mitochondrial-derived vesicles (MDVs) transfer mitochondrial content to lysosomes and peroxisomes. A study now reveals that MDVs deliver β-barrel proteins and fully assembled mitochondrial complexes for lysosomal degradation, establishing an important role for MDVs in mitochondrial protein quality control.
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References
Song, J., Herrmann, J. M. & Becker, T. Nat. Rev. Mol. Cell Biol. 22, 54–70 (2021).
König, T. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00798-4 (2021).
Soubannier, V. et al. Curr. Biol. 22, 135–141 (2012).
Neuspiel, M. et al. Curr. Biol. 18, 102–108 (2008).
McLelland, G. L. et al. EMBO J. 33, 282–295 (2014).
McLelland, G. L. et al. J. Cell Biol. 214, 275–291 (2016).
Suguira, A. et al. Nature 542, 251–254 (2017).
Matheoud, D. et al. Cell 166, 314–327 (2016).
Hughes, A. L. et al. eLife 5, e13943 (2016).
Schuler, M. H. et al. Mol. Cell 81, 3786–3802 (2021).
Phu, L. et al. Mol. Cell 77, 1107–1123 (2020).
Adachi, Y. et al. Mol. Cell 63, 1034–1043 (2016).
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Winter, D., Becker, T. Surveying the mitochondrial proteome. Nat Cell Biol 23, 1216–1217 (2021). https://doi.org/10.1038/s41556-021-00801-y
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DOI: https://doi.org/10.1038/s41556-021-00801-y
