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Organelles

Endoplasmic reticulum tethering by desmosomes

Desmosomes and keratin are now found to regulate the distribution and dynamics of the endoplasmic reticulum (ER). This suggests that a range of ER functions may be coordinated by this intercellular adhesive and cytoskeletal network.

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Fig. 1: Possible consequences of ER-desmosome tethering.

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Correspondence to Robert M. Harmon or Cara J. Gottardi.

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Harmon, R.M., Gottardi, C.J. Endoplasmic reticulum tethering by desmosomes. Nat Cell Biol 25, 796–797 (2023). https://doi.org/10.1038/s41556-023-01144-6

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