The nuclear envelope participates in the spatial regulation of DNA repair, but the mechanisms behind this are unclear. A study now reports that a nuclear envelope-localized nuclease, NUMEN/ENDOD1, guides the choice of DNA-repair pathway by inhibiting the resection of DNA ends and aberrant recombination, ensuring genome stability.
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Audibert, S., Soutoglou, E. Guiding DNA repair at the nuclear periphery. Nat Cell Biol 25, 928–930 (2023). https://doi.org/10.1038/s41556-023-01164-2
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DOI: https://doi.org/10.1038/s41556-023-01164-2
