Molecular insight into mechanisms that mediate the selective autophagy of lipid droplets (that is, lipophagy) has been lacking. This study identifies spartin, a protein mutated in a complex hereditary spastic paraplegia called Troyer syndrome, as a receptor that targets lipid droplets to the lysosome for degradation.
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References
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This is a summary of: Chung, J. et al. The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01178-w (2023).
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Spartin is a receptor for the autophagy of lipid droplets. Nat Cell Biol 25, 1085–1086 (2023). https://doi.org/10.1038/s41556-023-01201-0
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DOI: https://doi.org/10.1038/s41556-023-01201-0
