β-propeller protein-associated neurodegeneration (BPAN) is caused by loss of functional WIPI4. A new study reports that depletion of WIPI4 induces ferroptosis via changes in mitochondrial membrane lipids, independently of the role of WIPI4 in autophagy, providing insights into the cause of neurodegeneration in BPAN.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mizushima, N. & Levine, B. N. Engl. J. Med. 383, 1564–1576 (2020).
Osawa, T. & Noda, N. N. Protein Sci. 28, 1005–1012 (2019).
Shimizu, T. et al. Hum. Mol. Genet. 32, 2623–2637 (2023).
Stavoe, A. K. H. & Holzbaur, E. L. F. Annu. Rev. Cell Dev. Biol. 35, 477–500 (2019).
Zhu, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01373-3 (2024).
Jiang, X., Stockwell, B. R. & Conrad, M. Nat. Rev. Mol. Cell Biol. 22, 266–282 (2021).
Tan, J. X. & Finkel, T. Nature 609, 815–821 (2022).
Kagan, V. E. et al. Nat. Chem. Biol. 13, 81–90 (2017).
Choi, J. Y. et al. Mol. Microbiol. 99, 999–1014 (2016).
Monteiro-Cardoso, V. F. et al. Cell Rep. 40, 111364 (2022).
Hendricson, A. et al. J. Biol. Chem. 294, 12146–12156 (2019).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Liu, Y., Yang, H. WIPI4 loss linked to ferroptosis. Nat Cell Biol 26, 506–507 (2024). https://doi.org/10.1038/s41556-024-01359-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-024-01359-1
