Although critically important for protein function, post-translational modifications are complex and notoriously difficult to study. Now, the effects of O-GlcNAcylation on chaperone activity and the accompanying inhibition of amyloid fibril formation have been revealed, potentially yielding new routes to combat neurodegeneration.
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Radford, S.E., Karamanos, T.K. Finding the sweet spot for chaperone activity. Nat. Chem. 13, 397–399 (2021). https://doi.org/10.1038/s41557-021-00691-5
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DOI: https://doi.org/10.1038/s41557-021-00691-5
