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Natural product synthesis

Total synthesis of strychnan alkaloids

The synthesis of natural products with important biological properties has always fascinated chemists, but the development of rapid, efficient and stereoselective transformations remains challenging. Now, a strategy has been developed to produce several strychnan alkaloids through formation of a common bridged morphan core structure.

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Fig. 1: Formation of the bridged morphan main core and its valorization for the total synthesis of several strychnan alkaloids.

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Correspondence to Sylvain Canesi.

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Canesi, S. Total synthesis of strychnan alkaloids. Nat. Chem. 15, 1054–1055 (2023). https://doi.org/10.1038/s41557-023-01259-1

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