A ‘reverse translation’ strategy using gnotobiotic mice ascertains cause and effect relationships between bacterial members of the gut microbiota, dietary components and host physiology, which are difficult to establish in human nutritional trials.
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Walter, J. Establishing microbiome causality to tackle malnutrition. Nat Microbiol 9, 884–885 (2024). https://doi.org/10.1038/s41564-024-01653-6
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DOI: https://doi.org/10.1038/s41564-024-01653-6