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BIOPHYSICS

A new wrinkle on the brain

The folded structure of the human brain is a hallmark of our intelligence — an optimized packing of neurons into a confined space. Similar wrinkling in brain-on-a-chip experiments provides a way of understanding the physics of how this occurs.

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Fig. 1: Neural morphogenesis in organoids and embryo.

References

  1. Karzbrun, E., Kshirsagar, A., Cohen, S. R., Hanna, J. H. & Reiner, O. Nat. Phys. https://doi.org/10.1038/s41567-018-0046-7 (2018).

  2. Spear, P. C. & Erickson, C. A. Dev. Growth Differ. 54, 306–316 (2012).

    Article  Google Scholar 

  3. Fernández, V., Llinares-Benadero, C. & Borrell, V. EMBO J. 35, 1021–1044 (2016).

    Article  Google Scholar 

  4. Taber, L. A. Curr. Opin. Genetics Dev. 27, 7–13 (2014).

    Article  Google Scholar 

  5. Tallinen, T. et al. Nat. Phys. 12, 588–593 (2016).

    Article  Google Scholar 

  6. Bayly, P. V., Okamoto, R. J., Xu, G., Shi, Y. & Taber, L. A. Phys. Biol. 10, 016005 (2013).

    Article  ADS  Google Scholar 

  7. Reillo, I., de Juan Romero, C., García-Cabezas, M. A. & Borrell, V. Cereb. Cortex. 21, 1674–1694 (2011).

    Article  Google Scholar 

  8. Timoshenko, S. P. & Gere, J. M. Theory of Elastic Stability 2nd edn (McGraw-Hill, New York, 1961).

  9. Colas, J. F. & Schoenwolf, G. C. Dev. Dyn. 221, 117–145 (2001).

    Article  Google Scholar 

  10. Smith, J. L. & Schoenwolf, G. C. Cell Tissue Res. 252, 491–500 (1988).

    Article  Google Scholar 

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Correspondence to Larry A. Taber.

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Taber, L.A. A new wrinkle on the brain. Nature Phys 14, 435–436 (2018). https://doi.org/10.1038/s41567-018-0057-4

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