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Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?

Nature Reviews Microbiology volume 18, pages 261–262 (2020)Cite this article

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Resistance to the current first-line antimalarials threatens the control of malaria caused by the protozoan parasite Plasmodium falciparum and underscores the urgent need for new drugs with novel modes of action. Here, we present the argument that the parasite’s chloroquine resistance transporter (PfCRT) constitutes a promising target to combat multidrug-resistant malaria.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA

    Jennifer L. Small-Saunders & David A. Fidock

  2. Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA

    Laura M. Hagenah & David A. Fidock

Authors
  1. Jennifer L. Small-Saunders
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  2. Laura M. Hagenah
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  3. David A. Fidock
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Corresponding author

Correspondence to David A. Fidock.

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The authors declare no competing interests.

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World malaria report: https://www.who.int/publications-detail/world-malaria-report-2019#

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Small-Saunders, J.L., Hagenah, L.M. & Fidock, D.A. Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?. Nat Rev Microbiol 18, 261–262 (2020). https://doi.org/10.1038/s41579-020-0353-8

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