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Ageing

Not every organ ticks the same

Nature Reviews Nephrology (2024)Cite this article

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A new study describes the development of proteomics-based ageing clocks that calculate the biological age of specific organs and define features of extreme ageing associated with age-related diseases. Their findings support the notion that plasma proteins can be used to monitor the ageing rates of specific organs and disease progression.

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Fig. 1: Plasma proteomes from three healthy cohorts and two cohorts with Alzheimer disease (AD) were used to model organ-specific ageing and calculate age gaps.

References

  1. Oh, H. S. et al. Organ aging signatures in the plasma proteome track health and disease. Nature 624, 164–172 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Jafar, T. H. et al. Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level data. Ann. Intern. Med. 135, 73–87 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Westhoff, J. H. et al. Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension 52, 123–129 (2008).

    Article  CAS  PubMed  Google Scholar 

  4. Mogi, M. Effect of renin-angiotensin system on senescence. Geriatr. Gerontol. Int. 20, 520–525 (2020).

    Article  PubMed  Google Scholar 

  5. Kitada, K. et al. Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. J. Diabetes Complications 28, 604–611 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Wang, Y., Jin, M., Cheng, C. K. & Li, Q. Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives. Front. Endocrinol. (Lausanne) 14, 1238927 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Buchanan, S., Combet, E., Stenvinkel, P. & Shiels, P. G. Klotho, aging, and the failing kidney. Front. Endocrinol. (Lausanne) 11, 560 (2020).

    Article  PubMed  Google Scholar 

  8. Thielemans, R. et al. Unveiling the hidden power of uromodulin: a promising potential biomarker for kidney diseases. Diagnostics (Basel) 13, 3077 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Iacobazzi, D., Alvino, V. V., Caputo, M. & Madeddu, P. Accelerated cardiac aging in patients with congenital heart disease. Front. Cardiovasc. Med. 9, 892861 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Cortes-Canteli, M. & Iadecola, C. Alzheimer’s disease and vascular aging: JACC Focus Seminar. J. Am. Coll. Cardiol. 75, 942–951 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors thank Carl Grabitz, Hannover Medical School, for creating the original artwork.

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  1. Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany

    Khaoula Talbi & Anette Melk

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  1. Khaoula Talbi
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  2. Anette Melk
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Correspondence to Anette Melk.

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The authors declare no competing interests.

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Talbi, K., Melk, A. Not every organ ticks the same. Nat Rev Nephrol (2024). https://doi.org/10.1038/s41581-024-00842-0

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