A satiety circuit involving agouti-related peptide (AGRP)-expressing neurons in the arcuate nucleus (ARC) and neurons in the paraventricular nucleus of the hypothalamus (PVH) expressing the melanocortin 4 receptor (MC4R) and single minded 1 (SIM1) helps to control food intake in response to caloric deficiency. Using genetically enabled circuit mapping and real-time chemogenetic techniques, the authors found a class of anatomically and functionally distinct SIM1+ PVH neurons that express dynorphin and regulate satiety in an additive manner with MC4R+ PVH neurons.
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Li, M. M. et al. The paraventricular hypothalamus regulates satiety and prevents obesity via two genetically distinct circuits. Neuron https://doi.org/10.1016/j.neuron.2019.02.028 (2019)
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Lewis, S. Double satiety. Nat Rev Neurosci 20, 252 (2019). https://doi.org/10.1038/s41583-019-0164-y
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DOI: https://doi.org/10.1038/s41583-019-0164-y