The effects of obesity on the lateral hypothalamic area (LHA; a highly conserved brain region that mediates feeding behaviour) have been unclear to date. In this study, a combination of high-throughput single-cell RNA sequencing and longitudinal in vivo two-photon calcium imaging revealed that, in mice, glutamatergic neurons in the LHA act as a brake on feeding and supresses further food intake. Notably, the activity of these neurons is affected by diet-induced obesity, promoting further overeating.
References
Original article
Rossi, M. A. et al. Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding. Science 364, 1271–1274 (2019)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Leake, I. Putting the brakes on feeding. Nat Rev Neurosci 20, 513 (2019). https://doi.org/10.1038/s41583-019-0208-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41583-019-0208-3