Individuals with body integrity dysphoria (BID) feel as if they do not own one of their limbs, and seek its amputation. Saetta et al. used MRI to explore functional and structural differences in the cortex of 16 men with BID targeting the left leg. In these individuals, the sensorimotor area corresponding to the left leg showed reduced functional connectivity, and the left premotor cortex, which integrates multimodal sensory information, was atrophic. Moreover, the right superior parietal lobule, which is known to represent body image, showed functional and structural abnormalities, with its atrophy correlating with strength of desire for amputation.
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Saetta, G. et al. Neural correlates of body integrity dysphoria. Curr. Biol. https://doi.org/10.1016/j.cub.2020.04.001 (2020)
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Bray, N. Figuring out body integrity dysphoria. Nat Rev Neurosci 21, 351 (2020). https://doi.org/10.1038/s41583-020-0318-y
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DOI: https://doi.org/10.1038/s41583-020-0318-y