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Should 18F-FDG-PET imaging be used in the diagnosis of GCA?

18F-FDG-PET is not currently recommended for use in the diagnosis of cranial giant cell arteritis (GCA). A new study has compared 18F-FDG-PET with temporal artery biopsy and clinical diagnosis as gold standards, but is 18F-FDG-PET accurate enough to be used on temporal arteries?

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References

  1. Buttgereit, F. et al. Polymyalgia rheumatica and giant cell arteritis: a systematic review. JAMA 315, 2442–2458 (2016).

    Article  CAS  Google Scholar 

  2. Dejaco, C. et al. The spectrum of giant cell arteritis and polymyalgia rheumatica: revisiting the concept of the disease. Rheumatology 56, 506–515 (2017).

    CAS  PubMed  Google Scholar 

  3. Dejaco, C. et al. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice. Ann. Rheum. Dis. 77, 636–643 (2018).

    Article  Google Scholar 

  4. Sammel, A. M. et al. Diagnostic accuracy of PET/CT scan of the head, neck and chest for giant cell arteritis: the double-blinded giant cell arteritis and PET scan (GAPS) study. Arthritis Rheumatol. https://doi.org/10.1002/art.40864 (2019).

    Article  PubMed  Google Scholar 

  5. Nielsen, B. D. et al. Simple dichotomous assessment of cranial artery inflammation by conventional 18F-FDG PET/CT shows high accuracy for the diagnosis of giant cell arteritis: a case-control study. Eur. J. Nucl. Med. Mol. Imaging 46, 184–193 (2019).

    Article  CAS  Google Scholar 

  6. Slart, R. H. J. A. et al. FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC. Eur. J. Nucl. Med. Mol. Imaging 45, 1250–1269 (2018).

    Article  Google Scholar 

  7. Meignan, M. et al. Report on the Second International Workshop on interim positron emission tomography in lymphoma held in Menton, France, 8–9 April 2010. Leuk. Lymphoma 51, 2171–2180 (2010).

    Article  Google Scholar 

  8. Nielsen, B. D. et al. Three days of high-dose glucocorticoid treatment attenuates large-vessel 18F-FDG uptake in large-vessel giant cell arteritis but with a limited impact on diagnostic accuracy. Eur. J. Nucl. Med. Mol. Imaging 45, 1119–1128 (2018).

    Article  CAS  Google Scholar 

  9. Luqmani, R. et al. The role of ultrasound compared to biopsy of temporal arteries in the diagnosis and treatment of giant cell arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study. Health Technol. Assess. 20, 1–238 (2016).

    Article  Google Scholar 

  10. Conti, M. & Eriksson, L. Physics of pure and non-pure positron emitters for PET: a review and a discussion. EJNMMI Phys. 3, 8 (2016).

    Article  Google Scholar 

Download references

Acknowledgements

C.D. has received unrestricted grant support from Celgene.

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Correspondence to Christian Dejaco.

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D.C. declares that he has received consultancy and speaker fees from AbbVie, Celgene, Janssen-Cilag, Lilly, Mylan and Sanofi. C.D. declares that he has received consultancy fees and honoraria from AbbVie, Celgene, Lilly, MSD, Novartis, Pfizer, Roche, Sanofi and UCB.

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Camellino, D., Dejaco, C. Should 18F-FDG-PET imaging be used in the diagnosis of GCA?. Nat Rev Rheumatol 15, 388–390 (2019). https://doi.org/10.1038/s41584-019-0236-4

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