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Mutagenic effect of chemotherapy on sperm DNA and implications for family planning

Nature Reviews Urology volume 19, pages 511–512 (2022)Cite this article

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Some chemotherapeutic agents can induce distinct mutational signatures in healthy cells in patients with cancer. The effect of such mutational signatures on spermatogenesis is not fully understood but is of great clinical importance for counselling patients diagnosed with cancer planning to start a family after treatment.

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Authors and Affiliations

  1. Department of Urology, New York University Langone Health, New York, NY, USA

    Ari P. Bernstein

  2. Department of Urology, Montefiore Medical Center, Bronx, NY, USA

    Justin Loloi

  3. Miller School of Medicine, University of Miami, Miami, FL, USA

    Rohit Reddy & Christian Ramsoomair

  4. School of Medicine, University of Missouri-Columbia, Columbia, MO, USA

    Katherine Campbell

  5. Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA

    Francesco Maura & Ola Landgren

  6. Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, Miami, FL, USA

    Daniel Nassau, Emad Ibrahim & Ranjith Ramasamy

  7. Department of Urology, Nicklaus Children’s Hospital, Miami, FL, USA

    Daniel Nassau

Authors
  1. Ari P. Bernstein
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  2. Justin Loloi
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  3. Rohit Reddy
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  4. Christian Ramsoomair
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  5. Katherine Campbell
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  6. Francesco Maura
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  7. Ola Landgren
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  8. Daniel Nassau
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  9. Emad Ibrahim
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  10. Ranjith Ramasamy
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Corresponding author

Correspondence to Ranjith Ramasamy.

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The authors declare no competing interests.

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Bernstein, A.P., Loloi, J., Reddy, R. et al. Mutagenic effect of chemotherapy on sperm DNA and implications for family planning. Nat Rev Urol 19, 511–512 (2022). https://doi.org/10.1038/s41585-022-00625-x

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  • DOI: https://doi.org/10.1038/s41585-022-00625-x

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