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Prostate cancer is not just a man’s concern — the use of PSA screening in transgender women

Nature Reviews Urology volume 20, pages 323–324 (2023)Cite this article

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Transgender women remain at risk of prostate cancer and warrant consideration for PSA screening. However, current PSA reference ranges and guidelines are based on data from cisgender men. As these thresholds might be inappropriate in transgender women receiving gender-affirming hormones, we recommend that these patients should undergo screening for prostate cancer at regular intervals and further evaluation for PSA >1 ng/ml or rising PSA. Furthermore patient-centred dialogues should be initiated with patients to ensure awareness of prostate cancer risk.

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Authors and Affiliations

  1. Department of Urology, University of California, San Francisco, San Francisco, CA, USA

    Farnoosh Nik-Ahd & Matthew R. Cooperberg

  2. Department of Urology, University of California, San Diego, San Diego, CA, USA

    Jennifer T. Anger

  3. Department of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Stephen J. Freedland

  4. Section of Urology, Durham VA Medical Center, Durham, NC, USA

    Stephen J. Freedland

Authors
  1. Farnoosh Nik-Ahd
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  2. Jennifer T. Anger
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  3. Matthew R. Cooperberg
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  4. Stephen J. Freedland
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Correspondence to Farnoosh Nik-Ahd.

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The authors declare no competing interests.

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Nik-Ahd, F., Anger, J.T., Cooperberg, M.R. et al. Prostate cancer is not just a man’s concern — the use of PSA screening in transgender women. Nat Rev Urol 20, 323–324 (2023). https://doi.org/10.1038/s41585-023-00780-9

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