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Mosaic loss of chromosome Y in leukocytes matters

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Fig. 1: Comparison of the level of LOY mosaicism in blood leukocytes and buccal samples from each individual for the entire dataset of 121 studied subjects, sampled at the age of 93 years.

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The data that support the findings of this study are shown in Supplementary Table 1 and are available from the corresponding authors upon reasonable request.

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Acknowledgements

We thank E. Tiensuu Janson, S. Enroth and C. Polychronakos for review of the manuscript. K. Ström is acknowledged for collection of samples from the ULSAM cohort. The study was sponsored by funding from the European Research Council (ERC) Starting Grant, the Swedish Research Council, the Olle Enqvist Byggmästare Foundation, the Kjell and Märta Beijers Foundation to L.A.F. and by the Swedish Cancer Society, the Swedish Research Council, Konung Gustav V:s och Drottning Viktorias Frimurarestiftelse and the Science for Life Laboratory, Uppsala, to J.P.D. Genotyping and sequencing were performed by the SNP&SEQ Technology Platform in Uppsala, which is part of the Science for Life Laboratory at Uppsala University and is supported as a national infrastructure by the Swedish Research Council.

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Correspondence to Lars A. Forsberg or Jan P. Dumanski.

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J.P.D. and L.A.F. are cofounders and shareholders in Cray Innovation AB.

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Forsberg, L.A., Halvardson, J., Rychlicka-Buniowska, E. et al. Mosaic loss of chromosome Y in leukocytes matters. Nat Genet 51, 4–7 (2019). https://doi.org/10.1038/s41588-018-0267-9

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