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CANCER EVOLUTION

Springing an evolutionary trap on cancer

Nature Genetics volume 52, pages 361–362 (2020)Cite this article

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Cancer cells have the extraordinary evolutionary potential to adapt and acquire resistance to most conventional and targeted therapies. In a new study, Lin et al., develop a systematic approach to identify combination therapies that produce cancer traps, in which evading the first drug makes the cancer vulnerable to the second.

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Fig. 1: Examples and strategies to overcome therapy resistance in cancer.

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Authors and Affiliations

  1. Kronos Bio, Cambridge, MA, USA

    Charles Y. Lin

  2. Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA

    Charles Y. Lin

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  1. Charles Y. Lin
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Correspondence to Charles Y. Lin.

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The author declares no competing interests.

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Lin, C.Y. Springing an evolutionary trap on cancer. Nat Genet 52, 361–362 (2020). https://doi.org/10.1038/s41588-020-0608-3

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