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EPIGENOMICS

DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways

Nature Genetics volume 52, pages 554–556 (2020)Cite this article

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TET2 and DNMT3A mutations lead to similar long-term outcomes in blood cancers despite the antagonistic biochemical functions of their encoded proteins. A new study highlights the opposing effects of TET2 and DNMT3A mutations in shaping the early erythroid or myeloid bias of hematopoietic progenitors.

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Fig. 1: DNMT3A and TET2 mutations lead to divergent differentiation biases through opposing changes in DNA methylation at TF-binding sites.

References

  1. Bestor, T. H., Edwards, J. R. & Boulard, M. Proc. Natl Acad. Sci. USA 112, 6796–6799 (2015).

    Article  CAS  Google Scholar 

  2. Sperling, A. S., Gibson, C. J. & Ebert, B. L. Nat. Rev. Cancer 17, 5–19 (2017).

    Article  CAS  Google Scholar 

  3. Jaiswal, S. & Libby, P. Nat. Rev. Cardiol. 17, 137–144 (2020).

    Article  Google Scholar 

  4. Izzo, F. et al. Nat. Genet. 52, 378–387 (2020).

    Article  CAS  Google Scholar 

  5. Pronier, E. et al. Blood 118, 2551–2555 (2011).

    Article  CAS  Google Scholar 

  6. Moran-Crusio, K. et al. Cancer Cell 20, 11–24 (2011).

    Article  CAS  Google Scholar 

  7. Rasmussen, K. D. et al. Genes Dev. 29, 910–922 (2015).

    Article  CAS  Google Scholar 

  8. López-Moyado, I. F. et al. Proc. Natl Acad. Sci. USA 116, 16933–16942 (2019).

    Article  Google Scholar 

  9. Yin, Y. et al. Science 356, eaaj2239 (2017).

    Article  Google Scholar 

  10. Kaya-Okur, H. S. et al. Nat. Commun. 10, 1930 (2019).

    Article  Google Scholar 

  11. Zhang, X. et al. Nat. Genet. 48, 1014–1023 (2016).

    Article  CAS  Google Scholar 

  12. Barnett, K. R. et al. Mol. Cell 77, 1350–1364.e6 (2020).

    Article  CAS  Google Scholar 

  13. Guryanova, O. A. et al. Leukemia 30, 1133–1142 (2016).

    Article  CAS  Google Scholar 

  14. Quivoron, C. et al. Cancer Cell 20, 25–38 (2011).

    Article  CAS  Google Scholar 

  15. Meisel, M. et al. Nature 557, 580–584 (2018).

    Article  CAS  Google Scholar 

  16. Ostrander, E. L. et al. Stem Cell Rep. 14, 551–560 (2020).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA

    Isaac F. López-Moyado & Anjana Rao

  2. Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA

    Isaac F. López-Moyado & Anjana Rao

  3. Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA

    Isaac F. López-Moyado & Anjana Rao

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  1. Isaac F. López-Moyado
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  2. Anjana Rao
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Correspondence to Anjana Rao.

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López-Moyado, I.F., Rao, A. DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways. Nat Genet 52, 554–556 (2020). https://doi.org/10.1038/s41588-020-0641-2

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