Pachytene Piwi-interacting RNAs (piRNAs) are abundant small non-coding RNAs expressed in mammalian germ lines. A new study indicates that, among the diverse pool of piRNA sequences, a small number act as highly selective guides that induce cleavage of coding and non-coding transcripts, thus promoting piRNA generation and regulating gene expression.
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Aravin, A.A. Pachytene piRNAs as beneficial regulators or a defense system gone rogue. Nat Genet 52, 644–645 (2020). https://doi.org/10.1038/s41588-020-0656-8
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DOI: https://doi.org/10.1038/s41588-020-0656-8
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The birth of piRNAs: how mammalian piRNAs are produced, originated, and evolved
Mammalian Genome (2022)