How ‘difficult’ is it for somatic evolution to produce a cell that is capable of leaving the primary tumor and growing in a distant organ? In this issue, Reiter et al. assess genetic diversity across metastatic lesions and identify a tight selective bottleneck preceding distant metastasis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
Purchase on Springer Link
Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Greaves, M. & Maley, C. C. Nature 481, 306–313 (2012).
Nowell, P. C. Science 194, 23–28 (1976).
Priestley, P. et al. Nature 575, 210–216 (2019).
Martincorena, I. et al. Cell 171, 1029–1041.e21 (2017).
Campbell, P. J. et al. Nature 578, 82–93 (2020).
Hu, Z. et al. Nat. Genet. 51, 1113–1122 (2019).
Reiter, J. G. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0633-2 (2020).
Hu, Z., Li, Z., Ma, Z. & Curtis, C. Nat. Genet. https://doi.org/10.1038/s41588-020-0628-z (2020).
Ryser, M. D. et al. Nat. Commun. 11, 1 (2020).
Casasent, A. K. et al. Cell 172, 205–217.e12 (2018).
Naxerova, K. et al. Science 357, 55–60 (2017).
Corces, M. R. et al. Science 362, eaav1898 (2018).
Sottoriva, A. et al. Nat. Genet. 47, 209–216 (2015).
Williams, M. J. et al. Nat. Genet. 50, 895–903 (2018).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Graham, T.A., Shibata, D. Navigating the path to distant metastasis. Nat Genet 52, 642–643 (2020). https://doi.org/10.1038/s41588-020-0660-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-020-0660-z
This article is cited by
-
Key processes in tumor metastasis and therapeutic strategies with nanocarriers: a review
Molecular Biology Reports (2024)
-
Steps in metastasis: an updated review
Medical Oncology (2021)