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Linking human sympathoadrenal development and neuroblastoma

Nature Genetics volume 53, pages 593–594 (2021)Cite this article

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Cells resembling human fetal adrenal neuroblasts have been identified as major neuroblastoma cancer cells through single-cell mRNA comparison. Tumor risk stratification correlates with the differentiation of neuroblast-like neuroblastoma cells.

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Fig. 1: Schematic illustration of the changing composition of the human adrenal medulla during fetal development and the correlation with the stage-dependent composition of neuroblastoma.

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  1. Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Neuroscience Center, Goethe-University, Frankfurt am Main, Germany

    Hermann Rohrer

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  1. Hermann Rohrer
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Correspondence to Hermann Rohrer.

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Rohrer, H. Linking human sympathoadrenal development and neuroblastoma. Nat Genet 53, 593–594 (2021). https://doi.org/10.1038/s41588-021-00845-8

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