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CARDIOVASCULAR DISEASE

The regulatory network architecture of cardiometabolic diseases

Nature Genetics volume 54, pages 2–3 (2022)Cite this article

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Complex disease definitions often represent descriptive umbrella terms of symptoms rather than mechanistic entities. A new study shows how network-based approaches can help identify the mechanisms that link genes, cells, tissues and organs in cardiovascular diseases.

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Fig. 1: A mechanistic understanding of complex diseases requires a detailed mapping of the underlying perturbations across biological networks.

FrankRamspott / DigitalVision Vectors / Getty (proteome graphic); sumkinn / iStock / Getty Images Plus/Getty (transcriptome graphic)

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Authors and Affiliations

  1. Department of Pharmacology and Personalised Medicine, Faculty of Health and Medical Science, Maastricht University, Maastricht, The Netherlands

    Harald H. H. W. Schmidt

  2. Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria

    Jörg Menche

  3. Faculty of Mathematics, University of Vienna, Vienna, Austria

    Jörg Menche

  4. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

    Jörg Menche

Authors
  1. Harald H. H. W. Schmidt
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  2. Jörg Menche
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Correspondence to Harald H. H. W. Schmidt or Jörg Menche.

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The authors declare no competing interests.

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Schmidt, H.H.H.W., Menche, J. The regulatory network architecture of cardiometabolic diseases. Nat Genet 54, 2–3 (2022). https://doi.org/10.1038/s41588-021-00994-w

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