Cross-ancestry genome-wide association meta-analyses of neuroimaging genetics data from European and East Asian populations identified 339 genetic variant–hippocampal volumetric trait associations (23 new). Further cross-ancestry analyses revealed similar genetic effects on hippocampal volumetric traits between ancestries, with improved fine-mapping precision and predictive accuracy of polygenic scores in the under-represented East Asian population.
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References
Iglesias, J. E. et al. A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI. Neuroimage 115, 117–137 (2015). This paper reports the segmentation of hippocampal subfields.
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van der Meer, D. et al. Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Mol. Psychiatry 25, 3053–3065 (2020). This paper reports GWAS findings for hippocampal subfield volumes.
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This is a summary of: Liu, N. et al. Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes. Nat. Gen. https://doi.org/10.1038/s41588-023-01425-8 (2023).
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Cross-ancestry genetic discovery for hippocampal volumetric traits. Nat Genet 55, 1086–1087 (2023). https://doi.org/10.1038/s41588-023-01427-6
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DOI: https://doi.org/10.1038/s41588-023-01427-6
