Brain somatic mosaicism is linked to several neurological disorders and is thought to arise post-zygotically. A study suggests that pre-zygotic aneuploidy followed by post-zygotic partial reversion leads to a recurrent form of brain mosaicism-related epilepsy.
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Chung, C., Yang, X. & Gleeson, J.G. Post-zygotic brain mosaicism as a result of partial reversion of pre-zygotic aneuploidy. Nat Genet 55, 1784–1785 (2023). https://doi.org/10.1038/s41588-023-01552-2
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DOI: https://doi.org/10.1038/s41588-023-01552-2
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