Previous studies reported an effect of N6-methyladenosine (m6A) of super-enhancer RNAs (seRNAs) on chromatin accessibility and gene transcription. We investigated seRNA m6A levels in pancreatic ductal adenocarcinoma (PDAC) and found that aberrantly increased m6A methylation promoted local chromatin accessibility, resulting in increased transcription of oncogenes acting in PDAC progression.
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References
Li, W., Notani, D. & Rosenfeld, M. G. Enhancers as non-coding RNA transcription units: recent insights and future perspectives. Nat. Rev. Genet. 17, 207–223 (2016). This review article summarizes the characteristics and roles of enhancers.
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This is a summary of: Li, R. et al. Super-enhancer RNA m6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma. Nat. Genet. https://doi.org/10.1038/s41588-023-01568-8 (2023).
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m6A methylation of super-enhancer RNAs facilitates chromatin accessibility. Nat Genet 55, 2037–2038 (2023). https://doi.org/10.1038/s41588-023-01567-9
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DOI: https://doi.org/10.1038/s41588-023-01567-9
