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Functional genomics

Cell perturbation and lasers illuminate the genetics of latent blood cell traits

Nature Genetics volume 56, pages 16–18 (2024)Cite this article

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A new study combining experimental treatments of human blood cells from thousands of individuals with flow-cytometry-based phenotyping and then genome-wide association analyses identifies genetic loci associated with non-resting cell states. Integrating the results with disease association signals yields insights into the underlying biology.

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Fig. 1: Study overview.

References

  1. Smith, E. N. & Kruglyak, L. PLoS Biol. 6, e83 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  2. De Koning, D.-J. et al. Vet. Immunol. Immunopathol. 105, 343–352 (2005).

    Article  PubMed  Google Scholar 

  3. Ballinger, M. A. et al. Proc. Natl Acad. Sci. USA 120, e2214614120 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Homilius, M. et al. Nat. Genet. https://doi.org/10.1038/s41588-023-01600-x (2023).

  5. Chen, M.-H. et al. Cell 182, 1198–1213.e14 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Johnson, A. D. et al. Nat. Genet. 42, 608–613 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lee, M. N. et al. Science 343, 1246980 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Fairfax, B. P. et al. Science 343, 1246949 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Moyerbrailean, G. A. et al. Genome Res. 26, 1627–1638 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Sun, S. et al. Cells 10, 3386 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Thibord, F. et al. Circulation 146, 1225–1242 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Adamstein, N. H. et al. Eur. Heart J. 42, 896–903 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Mostafavi, H. et al. Nat. Genet. 55, 1866–1875 (2023).

    Article  CAS  PubMed  Google Scholar 

  14. Chen, S.-A. A. et al. Cell Genomics 3, 100273 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Oelen, R. et al. Nat. Commun. 13, 3267 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, USA

    Andrew D. Johnson

  2. The Framingham Heart Study, Framingham, MA, USA

    Andrew D. Johnson

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  1. Andrew D. Johnson
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Correspondence to Andrew D. Johnson.

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The author declares no competing interests.

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Johnson, A.D. Cell perturbation and lasers illuminate the genetics of latent blood cell traits. Nat Genet 56, 16–18 (2024). https://doi.org/10.1038/s41588-023-01623-4

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