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MICROBIOLOGY

T(oo)bAd

Nature Chemical Biology volume 15, pages 849–850 (2019)Cite this article

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An unusual terpene nucleoside, 1-TbAd, made by pathogenic mycobacteria acts as an antacid to block mycobacterial degradation in host cell vacuoles. The antacid activity acts to reduce acidity by neutralizing the pH of these degradative cell organelles.

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Fig. 1: The pathogenic bacterium Mycobacterium tuberculosis (Mtb, in green) is engulfed by macrophages inside the lung.

References

  1. Metchnikoff, E. Immunity in Infective Diseases (Cambridge University Press, United Kingdom, 1905).

  2. Sturgill-Koszycki, S. et al. Science 263, 678–681 (1994).

    Article  CAS  Google Scholar 

  3. Queval, C. J. et al. Cell Rep. 20, 3188–3198 (2017).

    Article  CAS  Google Scholar 

  4. Wong, D., Bach, H., Sun, J., Hmama, Z. & Av-Gay, Y. Proc. Natl Acad. Sci. USA 108, 19371–19376 (2011).

    Article  CAS  Google Scholar 

  5. Brodin, P. et al. PLoS Pathog. 6, e1001100 (2010).

    Article  Google Scholar 

  6. Buter, J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0336-0 (2019).

  7. Pethe, K. et al. Proc. Natl Acad. Sci. USA 101, 13642–13647 (2004).

    Article  CAS  Google Scholar 

  8. van der Wel, N. et al. Cell 129, 1287–1298 (2007).

    Article  CAS  Google Scholar 

  9. Simeone, R. et al. PLoS Pathog. 11, e1004650 (2015).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France

    Priscille Brodin & Eik Hoffmann

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  1. Priscille Brodin
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  2. Eik Hoffmann
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Correspondence to Priscille Brodin.

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The authors declare no competing interests.

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Brodin, P., Hoffmann, E. T(oo)bAd. Nat Chem Biol 15, 849–850 (2019). https://doi.org/10.1038/s41589-019-0347-x

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