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MEMBRANE PROTEINS

There is a lock for every key

Nature Chemical Biology volume 17, pages 1214–1216 (2021)Cite this article

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Chemoproteomics-enabled identification of the targets of a hydroxylated cholesterol metabolite, 20(S)-hydroxycholesterol, reveals it to be the first reported endogenous ligand of the sigma-2 receptor, a drug target for neurodegeneration and neuropathic pain.

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Fig. 1: A chemoproteomics screen using a photocrosslinkable and clickable oxysterol probe revealed that 20(S)-OHC is an endogenous ligand of the σ2 receptor (TMEM97).

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Authors and Affiliations

  1. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA

    Weizhi Yu & Jeremy M. Baskin

  2. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA

    Weizhi Yu & Jeremy M. Baskin

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  1. Weizhi Yu
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  2. Jeremy M. Baskin
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Correspondence to Jeremy M. Baskin.

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The authors declare no competing interests.

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Yu, W., Baskin, J.M. There is a lock for every key. Nat Chem Biol 17, 1214–1216 (2021). https://doi.org/10.1038/s41589-021-00908-1

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