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Gut microbiome

Moonlighting in the membrane

Nature Chemical Biology volume 19, pages 1436–1437 (2023)Cite this article

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Medicinal drugs can cross-react with gut bacterial proteins, but the identification of these off-target interactions is difficult. Multi-omic approaches enabled the discovery of a bacterial peptidase that is inhibited by diabetic drugs and unexpectedly influences bacterial fitness within complex microbial communities via a non-proteolytic mechanism.

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Fig. 1: Discovery of a human DPP4 homolog in B. thetaiotaomicron with non-proteolytic functions.

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Authors and Affiliations

  1. Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA

    Stavroula K. Hatzios

  2. Department of Chemistry, Yale University, New Haven, CT, USA

    Stavroula K. Hatzios

  3. Microbial Sciences Institute, Yale University, West Haven, CT, USA

    Stavroula K. Hatzios

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  1. Stavroula K. Hatzios
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Correspondence to Stavroula K. Hatzios.

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Hatzios, S.K. Moonlighting in the membrane. Nat Chem Biol 19, 1436–1437 (2023). https://doi.org/10.1038/s41589-023-01369-4

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