The K+ ion channel KCNQ2 modulates neuronal excitability and is targeted by retigabine, an anti-epileptic drug that enhances the probability of channel opening. New activators have now been discovered to increase unitary conductance through an unprecedented mechanism.
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Chen, J., Sanguinetti, M.C. A new twist to increase ion flow. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-023-01523-y
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DOI: https://doi.org/10.1038/s41589-023-01523-y