A previously unknown role is identified for a pathway that involves major histocompatibility complex class I and an inhibitory receptor, LILRB1, that regulates the phagocytosis of cancer cells by macrophages and contributes to resistance directed against the signal-regulatory protein CD47.
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References
Zou, W., Wolchok, J. D. & Chen, L. Sci. Transl. Med. 8, 328rv324 (2016).
Weiskopf, K. et al. Microbiol. Spectr. 4, https://doi.org/10.1128/microbiolspec.MCHD-0031-2016 (2016).
Barkal, A.A. et al. Nat. Immunol. https://doi.org/10.1038/s41590-017-0004-z (2017).
Kang, X. et al. Cell Cycle 15, 25–40 (2016).
Liu, X. et al. Nat. Med. 21, 1209–1215 (2015).
Liu, X., Kwon, H., Li, Z. & Fu, Y. X. J. Hematol. Oncol. 10, 12 (2017).
Xu, M. M. et al. Immunity 47, 363–373 (2017).
Garcia-Lora, A., Algarra, I. & Garrido, F. J. Cell. Physiol. 195, 346–355 (2003).
Manavalan, J. S. et al. Transpl. Immunol. 11, 245–258 (2003).
de Goeje, P. L. et al. OncoImmunology 4, e1014242 (2015).
Suciu-Foca, N. et al. J. Immunol. 178, 7432–7441 (2007).
Zheng, J. et al. Nature 485, 656–660 (2012).
Kang, X. et al. Nat. Cell Biol. 17, 665–677 (2015).
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Zhang, C.C., Fu, YX. Another way to not get eaten. Nat Immunol 19, 6–7 (2018). https://doi.org/10.1038/s41590-017-0009-7
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DOI: https://doi.org/10.1038/s41590-017-0009-7
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