CD8+ tissue-resident memory T cells (TRM cells) in two mucosal tissues, the skin and the female reproductive tract, proliferate in situ to generate a secondary pool of TRM cells that does not exit into the circulation.
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References
Beura, L. K. et al. Nat. Immunol. https://doi.org/10.1038/s41590-017-0029-3 (2018).
Park, S. L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-017-0027-5 (2018).
Gebhardt, T. et al. Nature 477, 216–219 (2011).
Masopust, D., Vezys, V., Wherry, E. J., Barber, D. L. & Ahmed, R. J. Immunol. 176, 2079–2083 (2006).
Nolz, J. C. & Harty, J. T. Immunity 34, 781–793 (2011).
Fraser, K. A., Schenkel, J. M., Jameson, S. C., Vezys, V. & Masopust, D. Immunity 39, 171–183 (2013).
Schenkel, J. M. et al. J. Immunol. 196, 3920–3926 (2016).
Mackay, L. K. et al. Nat. Immunol. 14, 1294–1301 (2013).
Takamura, S. et al. J. Exp. Med. 213, 3057–3073 (2016).
Wakim, L. M., Woodward-Davis, A. & Bevan, M. J. Proc. Natl. Acad. Sci. USA 107, 17872–17879 (2010).
Shin, H. & Iwasaki, A. Nature 491, 463–467 (2012).
Mohammed, J. et al. Nat. Immunol. 17, 414–421 (2016).
Ely, K. H. et al. J. Immunol. 170, 1423–1429 (2003).
Vezys, V. et al. Nature 457, 196–199 (2009).
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Low, J.S., Kaech, S.M. Trials and Tribble-ations of tissue TRM cells. Nat Immunol 19, 102–103 (2018). https://doi.org/10.1038/s41590-017-0031-9
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DOI: https://doi.org/10.1038/s41590-017-0031-9
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