The transcription factor Aire restrains the transcriptional duration and amplitude of tissue-specific self-antigens by opposing the activity of the chromatin remodeler Brg1—a process required for immune tolerance.
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Bortnick, A., Murre, C. mTECs Aire on the side of caution. Nat Immunol 19, 100–101 (2018). https://doi.org/10.1038/s41590-017-0033-7
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DOI: https://doi.org/10.1038/s41590-017-0033-7