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Stressed-out ROS take a silent death route

Detrimental levels of intracellular reactive oxygen species engage a caspase-independent and non-inflammatory cell death called ‘oxeiptosis’ that serves as an important mechanism in diminishing inflammation.

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Fig. 1: Toxic levels of ROS trigger a non-inflammatory, caspase-independent form of cell death called ‘oxeiptosis’.

References

  1. Holmström, K. M. & Finkel, T. Nat. Rev. Mol. Cell Biol. 15, 411–421 (2014).

    Article  PubMed  Google Scholar 

  2. Nathan, C. & Cunningham-Bussel, A. Nat. Rev. Immunol. 13, 349–361 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Holze, C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-017-0013-y (2017).

  4. Wang, Z., Jiang, H., Chen, S., Du, F. & Wang, X. Cell 148, 228–243 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. Blander, J. M. Nat. Rev. Immunol. 14, 601–618 (2014).

    Article  CAS  PubMed  Google Scholar 

  6. Kesavardhana, S. et al. J. Exp. Med. 214, 2217–2229 (2017).

    Article  CAS  PubMed  Google Scholar 

  7. Kuriakose, T. et al. Sci. Immunol. 1, aag2045 (2016).

    Article  PubMed Central  Google Scholar 

  8. Newton, K. et al. Science 343, 1357–1360 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. Baird, L. & Dinkova-Kostova, A. T. Arch. Toxicol. 85, 241–272 (2011).

    Article  CAS  PubMed  Google Scholar 

  10. Sevrioukova, I. F. Antioxid. Redox Signal. 14, 2545–2579 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. O’Mealey, G. B. et al. J. Cell Sci. 130, 3467–3480 (2017).

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Thirumala-Devi Kanneganti.

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Kesavardhana, S., Kanneganti, TD. Stressed-out ROS take a silent death route. Nat Immunol 19, 103–105 (2018). https://doi.org/10.1038/s41590-017-0034-6

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