Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HUMAN ANTIBODIES

High-affinity IgA against microbial glycans

Nature Immunology volume 19, pages 514–515 (2018)Cite this article

Subjects

Human affinity-matured antibodies to Klebsiella pneumoniae lipopolysaccharide O-antigen have different patterns of glycan fine specificity without being polyreactive. These antibodies might constitute an important mechanism for homeostatic control of the intestinal microbiome.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Glycan-specific antibody-mediated control of gut microbiota.

References

  1. Pabst, O., Cerovic, V. & Hornef, M. Trends Immunol. 37, 287–296 (2016).

    Article  PubMed  CAS  Google Scholar 

  2. Macpherson, A. J. et al. Science 288, 2222 (2000).

    Article  PubMed  CAS  Google Scholar 

  3. Rollenske, T. et al. Nat. Immunol. https://doi.org/10.1038/s10.1038/s41590-018-0106-2 (2018).

  4. Bunker, J. J. et al. Immunity 43, 541–553 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Bunker, J. J. et al. Science 358, eaan6619 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. McKenna, M. Nature 499, 394–396 (2013).

    Article  PubMed  CAS  Google Scholar 

  7. Paczosa, M. K. & Mecsas, J. Microbiol. Mol. Biol. Rev. 80, 629–661 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Hansen, D. S. et al. J. Clin. Microbiol. 37, 56–62 (1999).

    PubMed  PubMed Central  CAS  Google Scholar 

  9. Pennini, M. E. et al. Nat. Commun. 8, 1991 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Szijártó, V. et al. Virulence 8, 1203–1215 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Guachalla, L. M. et al. Sci. Rep. 7, 6635 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Lee, J. et al. Nat. Med. 22, 1456–1464 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical Engineering at The University of Texas at Austin, Austin, Texas, USA

    Jiwon Lee & George Georgiou

Authors
  1. Jiwon Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. George Georgiou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to George Georgiou.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, J., Georgiou, G. High-affinity IgA against microbial glycans. Nat Immunol 19, 514–515 (2018). https://doi.org/10.1038/s41590-018-0116-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-018-0116-0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing