Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

T CELL MOTILITY

CCR7 fuels and LFA-1 grips

Nature Immunology volume 19, pages 516–518 (2018)Cite this article

Subjects

Naive T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals that T cells remain highly responsive to their microenvironment via instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The balance of actin retrograde flow and adhesion regulates migration efficiency.

References

  1. Schulz, O., Hammerschmidt, S. I., Moschovakis, G. L. & Forster, R. Annu. Rev. Immunol. 34, 203–242 (2016).

    Article  PubMed  CAS  Google Scholar 

  2. Alon, R. & Dustin, M. L. Immunity 26, 17–27 (2007).

    Article  PubMed  CAS  Google Scholar 

  3. Springer, T. A. & Dustin, M. L. Curr. Opin. Cell Biol. 24, 107–115 (2012).

    Article  PubMed  CAS  Google Scholar 

  4. Woolf, E. et al. Nat. Immunol. 8, 1076–1085 (2007).

    Article  PubMed  CAS  Google Scholar 

  5. Worbs, T., Mempel, T. R., Bolter, J., von Andrian, U. H. & Forster, R. J. Exp. Med. 204, 489–495 (2007).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Hons, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0109-z (2018).

  7. Paluch, E. K., Aspalter, I. M. & Sixt, M. Annu. Rev. Cell Dev. Biol. 32, 469–490 (2016).

    Article  PubMed  CAS  Google Scholar 

  8. Nordenfelt, P. et al. Nat. Commun. 8, 2047 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Jacobelli, J., Bennett, F. C., Pandurangi, P., Tooley, A. J. & Krummel, M. F. J. Immunol. 182, 2041–2050 (2009).

    Article  PubMed  CAS  Google Scholar 

  10. Overstreet, M. G. et al. Nat. Immunol. 14, 949–958 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Walch, J. M. et al. J. Clin. Invest. 123, 2663–2671 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Hickman, H. D. et al. Immunity 42, 524–537 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Te Boekhorst, V., Preziosi, L. & Friedl, P. Annu. Rev. Cell Dev. Biol. 32, 491–526 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physics and Astronomy and Department of Biology, University of Rochester, Rochester, NY, USA

    Patrick W. Oakes

  2. David H. Smith Center for Vaccine Biology and immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA

    Deborah J. Fowell

Authors
  1. Patrick W. Oakes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Deborah J. Fowell
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Deborah J. Fowell.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oakes, P.W., Fowell, D.J. CCR7 fuels and LFA-1 grips. Nat Immunol 19, 516–518 (2018). https://doi.org/10.1038/s41590-018-0118-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-018-0118-y

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing