Single-cell transcriptomic analysis shows that B cells experience a continuum of cyclic transitional states during the germinal center (GC) reaction; this pattern is lost in GC-derived follicular lymphoma cells, which seem to be heterogeneous and desynchronized.
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Basso, K. Singling out the out-of-tune in lymphoma. Nat Immunol 19, 903–905 (2018). https://doi.org/10.1038/s41590-018-0189-9
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DOI: https://doi.org/10.1038/s41590-018-0189-9