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IMMUNOPATHOLOGY

Glucocorticoids and NK cell PD-1

Nature Immunology volume 19, pages 908–910 (2018)Cite this article

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Immune responses have the potential to induce life-threatening conditions. A novel multi-system pathway in which neuroendocrine signaling induces expression of the checkpoint receptor PD-1 on NK cells is an important mechanism for protection against cytokine-mediated disease during viral infection.

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Fig. 1: Danger that results from elevated amounts of cytokines is sensed by the neuroendocrine system to regulate the expression of PD-1 on NK cells and the production of IFN-γ by these cells.

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  1. Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, and The Warren Alpert Medical School, Brown University, Providence, RI, USA

    Christine A. Biron

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  1. Christine A. Biron
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Correspondence to Christine A. Biron.

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Biron, C.A. Glucocorticoids and NK cell PD-1. Nat Immunol 19, 908–910 (2018). https://doi.org/10.1038/s41590-018-0190-3

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