Cell-type-specific regulation of gene expression by transcription factors is a fundamental principle of biology. New findings show that microRNA-mediated control of target-gene expression is also dependent on the cellular context.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Bartel, D. P. Cell 173, 20–51 (2018).
Lee, T. I. & Young, R. A. Cell 152, 1237–1251 (2013).
Farnham, P. J. Nat. Rev. Genet. 10, 605–616 (2009).
Hsin, J.-P., Lu, Y., Loeb, G.B., Leslie, C.S. & Rudensky, A.Y. Nat. Immunol. https://doi.org/10.1038/s41590-018-0208-x (2018).
Jin, H. Y. & Xiao, C. Front. Genet. 6, 328 (2015).
Lu, L. F. et al. Immunity 43, 52–64 (2015).
Lai, M. et al. Nat. Commun. 7, 12207 (2016).
Nam, J. W. et al. Mol. Cell 53, 1031–1043 (2014).
Jin, H. Y. et al. PLoS Genet. 13, e1006623 (2017).
Erson-Bensan, A. E. & Begik, O. MicroRNA 6, 97–101 (2017).
Lewis, C. J., Pan, T. & Kalsotra, A. Nat. Rev. Mol. Cell Biol. 18, 202–210 (2017).
Nishikura, K. Nat. Rev. Mol. Cell Biol. 17, 83–96 (2016).
Jin, H. Y. et al. Front. Genet. 6, 340 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Chen, P., Liao, K. & Xiao, C. MicroRNA says no to mass production. Nat Immunol 19, 1040–1042 (2018). https://doi.org/10.1038/s41590-018-0215-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-018-0215-y