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Neuroimmunology

Targeting fibrin in neurodegeneration

Nature Immunology volume 19, pages 1149–1150 (2018)Cite this article

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Deposition of fibrin in the brain and central nervous system occurs after injury or disease. This process unmasks a conserved cryptic epitope of fibrin that activates microglia; blocking this interaction can limit inflammation and neurotoxicity.

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Fig. 1: Physiological and pathological functions of fibrin, and the amino-acid positions relevant for fibrin polymerization (γ400–411) and the cryptic loop, which mediates the activation of innate immunity and is targeted by mAb 5B8 (γ377–395).

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  1. Neuroimmunology and Multiple Sclerosis Research, Neurology Clinic, University Hospital Zurich, University Zurich, Zurich, Switzerland

    Roland Martin

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  1. Roland Martin
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Correspondence to Roland Martin.

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Martin, R. Targeting fibrin in neurodegeneration. Nat Immunol 19, 1149–1150 (2018). https://doi.org/10.1038/s41590-018-0241-9

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