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IMMUNOMETABOLISM

Metabolic requirements for expanding and arming a clone army

A new target for controlling T cell responses adds to the list of key processes dependent on the synthesis of tetrahydrobiopterin, which is essential for neurotransmitter and nitric-oxide production and pain control.

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Fig. 1: BH4 has a key role in T cell licensing.

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Correspondence to Andrew L. Mellor.

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A.L.M. is a scientific consultant for NewLink Genetics and receives income and share options for this service.

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Mellor, A.L., Huang, L. Metabolic requirements for expanding and arming a clone army. Nat Immunol 20, 118–120 (2019). https://doi.org/10.1038/s41590-018-0299-4

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