Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RHEUMATOID ARTHRITIS

N-myristoylation of AMPK controls T cell inflammatory function

In patients with rheumatoid arthritis, decreased abundance of the N-myristoyltransferase NMT1 in CD4+ T cells prevents N-myristoylation of the AMP-activated protein kinase AMPK and its localization to the lysosomal membrane, which leads to increased activation of the metabolic checkpoint kinase complex mTORC1 and proinflammatory T cell phenotypes.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Reduced abundance of NMT1 in CD4+ T cells from patients with RA leads to unrestrained mTORC1 activity.

References

  1. Udenwobele, D. I. et al. Front. Immunol. 8, 751 (2017).

    Article  Google Scholar 

  2. Wen, Z. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0296-7 (2019).

    Article  PubMed  Google Scholar 

  3. Rampoldi, F. et al. J. Immunol. 195, 4228–4243 (2015).

    Article  CAS  Google Scholar 

  4. Weyand, C. M., Zeisbrich, M. & Goronzy, J. J. Curr. Opin. Immunol. 46, 112–120 (2017).

    Article  CAS  Google Scholar 

  5. Oakhill, J. S. et al. Proc. Natl Acad. Sci. USA 107, 19237–19241 (2010).

    Article  CAS  Google Scholar 

  6. Zhang, C. S. et al. Cell Metab. 20, 526–540 (2014).

    Article  CAS  Google Scholar 

  7. Lin, S. C. & Hardie, D. G. Cell Metab. 27, 299–313 (2018).

    Article  CAS  Google Scholar 

  8. Bruyn, G. A. et al. Ann. Rheum. Dis. 67, 1090–1095 (2008).

    Article  CAS  Google Scholar 

  9. Deng, L. et al. Cell Death Dis. 9, 1143 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David K. Finlay.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Finlay, D.K. N-myristoylation of AMPK controls T cell inflammatory function. Nat Immunol 20, 252–254 (2019). https://doi.org/10.1038/s41590-019-0322-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0322-4

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing