The first detailed investigation of CD8+ tumor-infiltrating T cell differentiation in the hours after cells enter a tumor has yielded an unexpected twist. Naive T cells veer away from effector fate and enter the path towards exhaustion much earlier than expected.
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Acknowledgements
The authors thank A. Rao for comments. P.G.H. acknowledges support from National Institutes of Health (NIH) grants AI040127 and AI109842, and La Jolla Institute for Immunology institutional funds. B.D. is a Cancer Research Institute Irvington fellow supported by the Cancer Research Institute (CRI4681).
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P.G.H. is a founder of CalciMedica, Inc, and serves on its scientific advisory board. B.D. has no competing interests to disclose.
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Dash, B., Hogan, P.G. The road not taken en route to T cell exhaustion. Nat Immunol 24, 1402–1404 (2023). https://doi.org/10.1038/s41590-023-01596-w
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DOI: https://doi.org/10.1038/s41590-023-01596-w